Fenofibrate ameliorates testicular damage in rats with streptozotocin-induced type 1 diabetes: role of HO-1 and p38 MAPK.

Asmaa Mohamed Abdel-AzizSamah Mohammed Mahmoud AbozaidRehab Kamal Mohammed YousefMostafa Mourad MohammedHanaa Mohamed Khalaf

Published in: Pharmacological reports : PR (2020)

FEN treatment exerted a protective effect against streptozotocin-induced diabetic reproductive dysfunction not only through its powerful antioxidant and hypoglycemic effects, but also through its anti-inflammatory and anti-apoptotic effect via down-regulation of testicular p38 MAPK expression in diabetic rats.

Keyphrases

diabetic rats
oxidative stress
anti inflammatory
type diabetes
poor prognosis
cell death
germ cell
mouse model
insulin resistance
adipose tissue
metabolic syndrome
endothelial cells