Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot safety and feasibility randomised controlled trial.
Morgan Thomas RoseNatasha E HolmesGlenn M EastwoodSara VogrinFiona JamesJoseph F De LucaRinaldo BellomoStephen J WarrillowMichelle PhungSara L BarnesBrendan MurfinBen RogersBelinda LambrosBrennan CollisTrisha N PeelMonica A SlavinJason A TrubianoPublished in: Intensive care medicine (2024)
These findings support the safety, validity, and feasibility of direct enteral challenge for critically ill patients with PEN-FAST assessed low-risk penicillin allergy. The absence of false negative results was confirmed by subsequent negative repeat challenges. A relatively low recruitment to screened ratio suggests that more inclusive eligibility criteria and integration of allergy assessment into routine ICU processes are needed to optimise allergy delabelling in critical illness.
Keyphrases
- atopic dermatitis
- healthcare
- study protocol
- infectious diseases
- ejection fraction
- newly diagnosed
- clinical practice
- intensive care unit
- palliative care
- randomized controlled trial
- mechanical ventilation
- patient reported outcomes
- chronic pain
- extracorporeal membrane oxygenation
- adverse drug
- double blind
- health insurance