Platform trial for off-label oncology drugs using comprehensive genomic profiling under the universal public healthcare system: the BELIEVE trial.

Sae IshimaruTatsunori ShimoiKuniko SunamiMiho NakajimaYayoi AndoNatsuko OkitaKenichi NakamuraTaro ShibataYasuhiro FujiwaraNoboru Yamamoto

Published in: International journal of clinical oncology (2023)

The BELIEVE trial provides hope for patients with actionable genetic abnormalities by facilitating access to targeted therapies through off-label drug administration. It establishes a regulatory framework and promotes collaboration between industry and academia by expanding organ-specific and cross-organ biomarker-based treatments.

Keyphrases

phase iii
study protocol
phase ii
clinical trial
drug administration
healthcare
randomized controlled trial
palliative care
copy number
mental health
open label
gene expression
electronic health record