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Prognostic Value of Programmed Death Ligand-1 Expression on Tumor-Infiltrating Immune Cells in Patients Treated with Cisplatin-Based Combination Adjuvant Chemotherapy Following Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Retrospective Cohort Study.

Dong Hyeon LeeJae Yong JeongWan Song
Published in: OncoTargets and therapy (2021)
PD-L1 is widely expressed in ICs. Positive PD-L1 on ICs was significantly associated with shorter RFS in patients treated with cisplatin-based AC following RC. The present results support the use of adjuvant immunotherapy in "high-risk" patients with PD-L1-expressing ICs.
Keyphrases
  • muscle invasive bladder cancer
  • poor prognosis
  • early stage
  • wild type