Enhanced expression of cyclooxygenase-2 related multi-drug resistance gene in melanoma and osteosarcoma cell lines by TSG-6 secreted from canine adipose-derived mesenchymal stem/stromal cells.
Se-Jin YangJu-Hyun AnSu-Min ParkJeong-Hwa LeeHyung-Kyu ChaeKyung-Mi LeeWoo-Jin SongHwa Young YounPublished in: Veterinary medicine and science (2021)
TSG-6 mediated COX-2 up-regulation is a possible mechanism of chemoresistance development induced by ADSCs. These findings provide better understanding about the mechanism associated with ADSC-induced chemoresistance in cancer.