Autoantigen characterization in the lower esophageal sphincter muscle of patients with achalasia.
Ángel Alexis Priego-RaneroGhislain OpdenakkerNorma Uribe-UribeDiana Aguilar-LeónCarlos A Nuñez-ÁlvarezDiego Francisco Hernández-RamírezElizabeth Olivares-MartínezEnrique Coss-AdameMiguel A ValdovinosJanette Furuzawa-CarballedaGonzalo Torres-VillalobosPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)
Tissue-specific ectopic expression of GAD65 and PNMA/Ta2 and active MMP-9, associated with the presence of specific autoantibodies directed against these proteins, might participate in the pathophysiology of achalasia triggering and/or perpetuating autoimmune disease.