Clinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract Cancer Reveals Subtype-Specific Immune Signatures.
Kabir ModyPrerna JainSherif M El-RefaiNilofer S AzadDaniel J ZabranskyNilofer S AzadRachna T ShroffRobin Kate KelleyAnthony B El-KhoueiryAdam J HockenberryDenise LauGregory B LesinskiMark YarchoanPublished in: JCO precision oncology (2022)
BTC subtypes exhibit diverse DNA alterations, RNA inflammatory signatures, and immune biomarkers. The association between specific BTC anatomical subsets, molecular alterations, and immunophenotypes highlights new opportunities for therapeutic development.