Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer.
Huiqing ChenYajing XingJia XieJiuqing XieDong XingJie TangFan YangZhengfang YiWen-Wei QiuPublished in: RSC advances (2019)
A series of novel 3-nitro-4-chromanones were synthesized and their in vitro cytotoxicity was evaluated on castration-resistant prostate cancer cell (CRPC) lines using the sulforhodamine B (SRB) assay. The amide derivatives showed more potent antitumor activity than their corresponding ester derivatives. Most of the tested compounds showed less toxicity towards human fibroblasts (HAF) compared with the tumor cell lines. The optimal compound 36 possessed much more potent antiproliferative activity than the positive compound cisplatin. The colony formation, cell cycle distribution, apoptosis, transwell migration and wound healing assays of 36 were performed on CRPC cell lines.
Keyphrases
- cell cycle
- high throughput
- wound healing
- cell proliferation
- oxidative stress
- endothelial cells
- single cell
- anti inflammatory
- endoplasmic reticulum stress
- structure activity relationship
- cell therapy
- induced pluripotent stem cells
- cell death
- cell cycle arrest
- pluripotent stem cells
- oxide nanoparticles
- extracellular matrix
- mesenchymal stem cells