LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

Ani GrigoryanNovella GuidiKatharina SengerThomas LiehrKarin SollerGina MarkaAngelika VollmerYolanda MarkakiHeinrich LeonhardtChristian BuskeDaniel B LipkaChristoph PlassYi ZhengMedhanie A MulawHartmut GeigerMaria Carolina Florian

Published in: Genome biology (2018)

Collectively, our data show that chromatin architecture changes in aged stem cells are reversible by decreasing the levels of Cdc42 activity, revealing an unanticipated way to pharmacologically target LaminA/C expression and revert alterations of the epigenetic architecture in aged HSCs.

Keyphrases

stem cells
gene expression
dna methylation
genome wide
dna damage
transcription factor
poor prognosis
cell therapy
bone marrow
electronic health record
cell cycle
big data
long non coding rna
machine learning
artificial intelligence