Sensitivity of brain MRI and neurological examination for detection of upper motor neurone degeneration in amyotrophic lateral sclerosis.
Abram D NitertHarold H G TanRenée WalhoutNienke L KnijnenburgMichael A van EsJan Herman VeldinkJeroen HendrikseHenk-Jan WestenengLeonard H van den BergPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Motor CT is a more sensitive measure of UMN degeneration than UMN signs. Motor CT and pyramidal tract FD are discriminative between patients and controls. Brain MRI can monitor UMN degeneration before signs become clinically evident. These findings promote MRI as a potential biomarker for UMN progression in clinical trials in ALS.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- computed tomography
- clinical trial
- diffusion weighted imaging
- magnetic resonance
- end stage renal disease
- resting state
- dual energy
- white matter
- newly diagnosed
- image quality
- ejection fraction
- chronic kidney disease
- cerebral ischemia
- functional connectivity
- patient reported outcomes
- randomized controlled trial
- peritoneal dialysis
- loop mediated isothermal amplification
- multiple sclerosis
- sensitive detection
- patient reported