Five-year follow-up study on quantitative muscle magnetic resonance imaging in facioscapulohumeral muscular dystrophy: The link to clinical outcome.
Sanne C C VincentenKarlien MulDaniël van AsJulia J JansenLinda HeskampArend HeerschapBaziel G M van EngelenNicol C VoermansPublished in: Journal of cachexia, sarcopenia and muscle (2023)
This 5-year study showed significant changes in MRI and clinical outcome measures and a significant correlation between changes in MRI-CoS and changes in clinical outcome measures. In addition, we identified subgroups of patients that are most prone to radiological disease progression. This knowledge further establishes quantitative MRI parameters as prognostic biomarkers in FSHD and as efficacy biomarkers in upcoming clinical trials.
Keyphrases
- muscular dystrophy
- contrast enhanced
- magnetic resonance imaging
- clinical trial
- end stage renal disease
- diffusion weighted imaging
- ejection fraction
- high resolution
- newly diagnosed
- healthcare
- peritoneal dialysis
- duchenne muscular dystrophy
- prognostic factors
- skeletal muscle
- randomized controlled trial
- open label
- patient reported