Inflammation Causes Exacerbation of COVID-19: How about Skin Inflammation?
Mayumi KomineTuba Mussarat AnsaryMd Razib HossainKoji KamiyaMamitaro OhtsukiPublished in: International journal of molecular sciences (2022)
COVID-19 is a recently emerged viral infection worldwide. SARS-CoV-2, the causative virus, is believed to have emerged from bat coronaviruses, probably through host conversion. The bat coronavirus which has the highest gene homology to SARS-CoV-2 specifically infects deep forest bats in China whose habitat extends through the Middle East to Southern Europe. Host conversion might have occurred due to the deforestation by humans exposing wild bats to the environment they had never encountered before. SARS-CoV-2 infects cells through two mechanisms: through its receptor ACE2 with the help of enzyme TMPRSS and through membrane fusion with the help of elastases in the inflammatory condition. Obesity, hypertension, diabetes mellitus, and pulmonary diseases cause poor prognosis of COVID-19. Aging is another factor promoting poor prognosis. These diseases and aging cause low-level and persistent inflammation in humans, which can promote poor prognosis of COVID-19. Psoriasis and atopic dermatitis are the major inflammatory skin diseases. These inflammatory skin conditions, however, do not seem to cause poor prognosis for COVID-19 based on the epidemiological data accumulated so far. These mechanisms need to be elucidated.
Keyphrases
- sars cov
- poor prognosis
- long non coding rna
- oxidative stress
- respiratory syndrome coronavirus
- coronavirus disease
- atopic dermatitis
- induced apoptosis
- soft tissue
- insulin resistance
- chronic obstructive pulmonary disease
- wound healing
- skeletal muscle
- machine learning
- weight loss
- transcription factor
- physical activity
- gene expression
- cell cycle arrest
- electronic health record
- cell proliferation
- weight gain
- endoplasmic reticulum stress
- artificial intelligence
- respiratory failure
- glycemic control
- pi k akt
- high fat diet induced