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Dynamically decreased miR-671-5p expression is associated with oncogenic transformation and radiochemoresistance in breast cancer.

Xiaohui TanZhongwu LiShuchang RenKatayoon RezaeiQing PanAndrew T GoldsteinCharles J MacriDengfeng CaoRachel F BremSidney W Fu
Published in: Breast cancer research : BCR (2019)
miR-671-5p displays a dynamic decrease expression during the oncogenic transition of BC by suppressing FOXM1-mediated EMT and DNA repair. Therefore, miR-671-5p may serve as a novel biomarker for early BC detection as well as a therapeutic target for BC management.
Keyphrases
  • dna repair
  • poor prognosis
  • dna damage
  • transcription factor
  • epithelial mesenchymal transition
  • binding protein
  • dna damage response
  • oxidative stress
  • real time pcr