Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094.
Qiang WangYixuan ZhangMian WangYi TanXinxin HuHongwei HeChunling XiaoXuefu YouYiguang WangMaoluo GanPublished in: Scientific reports (2017)
Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range (IC50: 38.7 and 65.8 nM, respectively) and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains.
Keyphrases
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- endothelial cells
- papillary thyroid
- molecular docking
- escherichia coli
- photodynamic therapy
- anti inflammatory
- induced pluripotent stem cells
- high intensity
- squamous cell
- high resolution
- squamous cell carcinoma
- pluripotent stem cells
- silver nanoparticles
- signaling pathway
- mass spectrometry
- cell proliferation
- lymph node metastasis