Apremilast in Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Meta-analysis.

Riley K SpencerKareem G ElhageJoy Q JinMitchell S DavisMarwa HakimiTina BhutaniWilson Liao

Published in: Dermatology and therapy (2023)

Apremilast treatment in PP and PPP resulted in significant improvement in objective, palmoplantar-specific clinical parameters versus placebo, and comparable efficacy with methotrexate in PP. Limitations in interpreting these results include variations in palmoplantar-specific metrics used and risk of bias of included studies.

Keyphrases

high dose
randomized controlled trial
low dose
combination therapy
double blind
case control