Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
Wenbo QuXin ZhouXinjian JiangXian-Wei XieKaijian XuXia GuRuisi NaMinghui PiaoXiangwen XiNa SunXueyu WangXiang PengJun-Yan XuJiangtian TianJian ZhangJunli GuoMaomao ZhangYao ZhangZhen-Wei PanKun WangBo YuBin SunShuijie LiJinwei TianPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
These findings reveal that Gpr137b-ps plays an essential role in the regulation of macrophage autophagy, which is crucial for the progression of advanced atherosclerosis. Gpr137b-ps impairs the interaction of HSC70 with G3BP to regulate amino acid-mTORC1-autophagy signaling, and these results provide a new potential therapeutic direction for the treatment of advanced atherosclerosis.