Increased PVR Expression on Bone Marrow Macrophages May Promote Resistance to TIGIT Blockade in Multiple Myeloma.

Ester Lozano Mari-Pau Mena Gloria Garrabou Oriol Cardus Tania Díaz David F Moreno Joan Mañé-Pujol Marta Garrote Anthony Matthew Battram Natalia Tovar Maria Teresa Cibeira Luis-Gerardo Rodríguez-Lobato Joan Bladé Carlos Fernández de Larrea Laura Rosinol

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

IL-2 induced TIGIT on T cells in the BM where increased PVR expression resulted in cytotoxic T cell inhibition promoting PC survival and resistance to TIGIT blockade.

Keyphrases

poor prognosis
bone marrow
multiple myeloma
high glucose
endothelial cells