Axillary dissection versus axillary observation for low risk, clinically node-negative invasive breast cancer: a systematic review and meta-analysis.
Mahaveer S SanghaRose BakerMuneer AhmedPublished in: Breast cancer (Tokyo, Japan) (2021)
ALND does not cause a significant improvement in OS in women with clinically node-negative breast cancer. ALND may improve DFS in the short term by tailoring a proportion of patients towards chemotherapy. Our evidence suggests that when the administration of systemic therapy is balanced between the two arms, axillary de-escalation studies will likely find no difference in OS or DFS.
Keyphrases
- lymph node
- sentinel lymph node
- neoadjuvant chemotherapy
- end stage renal disease
- ultrasound guided
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- randomized controlled trial
- peritoneal dialysis
- squamous cell carcinoma
- stem cells
- open label
- clinical trial
- mesenchymal stem cells
- double blind
- childhood cancer