Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults.
Nancy E MoranMorgan J CichonKenneth M RiedlElizabeth M GraingerSteven J SchwartzJanet A NovotnyJohn W ErdmanSteven K ClintonPublished in: The American journal of clinical nutrition (2015)
(13)C-Lycopene combined with physiologic compartmental modeling provides a strategy for following complex in vivo metabolic processes in humans and reveals that postabsorptive trans-to-cis-lycopene isomerization, and not the differential bioavailability of isomers, drives tissue and plasma enrichment of cis-lycopene. This trial was registered at clinicaltrials.gov as NCT01692340.