X chromosome dosage and the genetic impact across human tissues.

Mette Hansen Viuff Anne Skakkebaek Emma B Johannsen Simon Chang Steen Bønlykke Pedersen Katrine Meyer Lauritsen Mette Glavind Bülow Pedersen Christian Trolle Jesper Just Claus Højbjerg Gravholt

Published in: Genome medicine (2023)

We highlight a tissue-specific and complex effect of X chromosome number on the transcriptome and methylome, elucidating both shared and non-shared gene-regulatory mechanism between SCAs.

Keyphrases

copy number
genome wide
gene expression
endothelial cells
single cell
pluripotent stem cells
induced pluripotent stem cells
dna methylation