Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling.

Xiangyu ZhangTrent D EvansSunny ChenIsmail SerginJeremiah StithamSe-Jin Jeong Astrid Rodriguez-Velez Yu-Sheng Yeh Arick C Park In-Hyuk Jung Abhinav Diwan Joel D Schilling Oren Rom Arif Yurdagul Slava Epelman Jaehyung Cho Irfan J LodhiBettina MittendorferBabak Razani

Published in: Circulation research (2023)

Our data provide the first mechanistic details of macrophage mTOR signaling in atherosclerosis and suggest that therapeutic measures aimed at modulating mTOR need to account for its dichotomous functions.

Keyphrases

cardiovascular disease
adipose tissue
cell proliferation
signaling pathway
transcription factor
electronic health record
pi k akt
data analysis