COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study.
Luca Saverio BelliChristophe DuvouxPaolo Angelo CortesiRita FacchettiSperanta IacobGiovanni PerriconeSylvie RadenneSara ContiDamiano PatronoGabriela BerlakovichAngus HannLuisa PasuloLluis CastellsFrancois FaitotOlivier DetryFederica InvernizziGiulia MaginiPaolo De SimoneIlias KounisMaria Cristina MorelliFernando Díaz-FontenlaBo-Göran EriczonCarmelo LoinazChris JohnstonLiliana GheorgheMickael LesurtelRenato RomagnoliDagmar KollmannM Thamara Pr PereraStefano FagiuoliDarius MirzaAudrey CoillyChristian TosoKrzysztof ZieniewiczLaure ElkriefVincent KaramRene AdamCaroline den HoedMarco MerliMassimo PuotiLuciano De CarlisGabriel C OniscuSalvatore PianoPaolo AngeliConstantino FondevilaWojciech G Polaknull nullPublished in: Gut (2021)
Increased mortality in LT candidates with COVID-19 (32.7%), reaching 45% in those with decompensated cirrhosis (DC) and Lab-MELD score of ≥15, was observed, with no significant difference between first and second waves of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with DC supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%).
Keyphrases
- sars cov
- respiratory failure
- coronavirus disease
- respiratory syndrome coronavirus
- dendritic cells
- extracorporeal membrane oxygenation
- heart failure
- mechanical ventilation
- cardiovascular events
- study protocol
- risk factors
- cross sectional
- double blind
- electronic health record
- type diabetes
- immune response
- ejection fraction
- adipose tissue
- insulin resistance
- free survival
- liver failure