Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression.
Xiaodan MaoHuifang LeiTianjin YiPingping SuShuting TangYao TongBinhua DongGuanyu RuanAlexander MusteaJalid SehouliPeng-Ming SunPublished in: Journal of experimental & clinical cancer research : CR (2022)
Lipid reprogramming induced by the TFEB-ERRα axis increases unsaturated fatty acid (UFA)-containing PCs, PG, PC/SM and pseudopodia, which enhance membrane fluidity via EMT signaling to promote EC progression. PG (18:1/22:6) + H induced by TFEB-ERRα axis was involved in tumorigenesis and PC (18:1/18:2) + HCOO was the ERRα-dependent lipid to mediate EC metastasis.