Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial.
Steven E KahnJohn E DeanfieldOle Kleist JeppesenScott S EmersonTrine Welløv BoesgaardHelen M ColhounRobert F KushnerIldiko LingvayBartolome BurgueraGrzegorz GajosDeborah Bade HornIrene M HramiakAnia M JastreboffAlexander KokkinosMichael MaengAna Laura S A MatosFrancisco J TinahonesA Michael LincoffDonna H Ryannull nullPublished in: Diabetes care (2024)
In people with preexisting cardiovascular disease and overweight or obesity but without diabetes, long-term semaglutide increases regression to biochemical normoglycemia and reduces progression to biochemical diabetes but does not slow glycemic progression over time.