Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP.

Jingxue MaRuiying MaXiaoyue ZhaoYingxiu WangShengxue LiaoCong NongFengling LuZhao LiangJunhui HuangYan HuangZhengxi Zhu Junjie Wang

Published in: Journal of immunology research (2023)

The results of the study extrapolate that Cyr61 plays a dominant role in Ang II-induced podocyte apoptosis. Additionally, Cyr61 may mediate the Ang II-induced podocyte apoptosis by promoting the expression of TNXIP.

Keyphrases

high glucose
angiotensin ii
oxidative stress
diabetic rats
endothelial cells
endoplasmic reticulum stress
poor prognosis
cell cycle arrest
cell death
vascular smooth muscle cells
drug induced
cell proliferation
diabetic nephropathy