Dual-MicroRNA-regulation of singlet oxygen generation by a DNA-tetrahedron-based molecular logic device.
Qing LinShijun CaiBing ZhouKemin WangLixin JianJin HuangPublished in: Chemical communications (Cambridge, England) (2021)
Endogenous miRNA expression patterns are extremely cell-type-specific, thereby offering high prediction accuracy for different cell identities. Here, a DNA-tetrahedron-based "AND" logic gate is utilized as a molecular device that recognizes dual-miRNA inputs through strand hybridization to activate a computation cascade that produces controlled singlet oxygen in live cells, resulting in the death of the target cell.