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Dual-MicroRNA-regulation of singlet oxygen generation by a DNA-tetrahedron-based molecular logic device.

Qing LinShijun CaiBing ZhouKemin WangLixin JianJin Huang
Published in: Chemical communications (Cambridge, England) (2021)
Endogenous miRNA expression patterns are extremely cell-type-specific, thereby offering high prediction accuracy for different cell identities. Here, a DNA-tetrahedron-based "AND" logic gate is utilized as a molecular device that recognizes dual-miRNA inputs through strand hybridization to activate a computation cascade that produces controlled singlet oxygen in live cells, resulting in the death of the target cell.
Keyphrases
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