Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers.
Yuta KobayashiAtsushi NiidaSatoshi NagayamaKoichi SaekiHiroshi HaenoKazuki K TakahashiShuto HayashiYuki OzatoHideyuki SaitoTakanori HasegawaHiromi NakamuraTaro ToboAkihiro KitagawaKuniaki SatoDai ShimizuHidenari HirataYuichi HisamatsuTakeo ToshimaYusuke YonemuraTakaaki MasudaShinichi MizunoMasahito KawazuShinji KohsakaToshihide UenoHiroyuki ManoSoichiro IshiharaMamoru UemuraMasaki MoriYuichiro DokiHidetoshi EguchiMasanobu OshimaYutaka SuzukiTatsuhiro ShibataKoshi MimoriPublished in: British journal of cancer (2023)
Our results demonstrate the heterogeneous acquisition of immune escape mechanisms in MSI-H CRCs by Darwinian selection, providing novel insights into ICI-based treatment strategies.
Keyphrases