Smooth Muscle Cell Klf4 Expression Is Not Required for Phenotype Modulation or Aneurysm Formation in Marfan Syndrome Mice.

Albert J Pedroza Alex R Dalal Rohan ShadNobu YokoyamaKen NakamuraOlivia MitchelCasey GillesWilliam Hiesinger Michael P Fischbein

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

is not required to initiate SMC phenotype modulation in MFS aneurysm but may exert regulatory control over chondrogenic genes expressed in highly dedifferentiated SMCs.

Keyphrases

smooth muscle
coronary artery
transcription factor
poor prognosis
single cell
mesenchymal stem cells
cell therapy
genome wide
abdominal aortic aneurysm
high fat diet induced
case report
type diabetes
aortic aneurysm
adipose tissue
metabolic syndrome
dna methylation
gene expression
genome wide analysis