Efficacy and Safety of Doravirine-Based Regimens in Real Life: A Prospective Monocentric French Study.
Magali GarciaJean Philippe MartellosioValentin GiraudGuillaume BéraudMélanie CatrouxFrance RoblotGwénael Le MoalPublished in: AIDS research and human retroviruses (2022)
Doravirine (DOR) efficacy and safety have been evaluated in adult naive or treated patients starting a DOR-based regimen between September 15, 2019, and December 31, 2020. Medical history and examination, laboratory results, and tolerance were assessed during the 48 weeks of follow-up. Among the 77 patients included, virological control (VC) was noticed for 66 patients at baseline. Median age was 51 years, and 62% were men. The most common reason for initiating a DOR-based therapy was toxicity (44; 67%) and, especially, weight gain. A virological suppression (VS) was maintained in 55 (83%) patients of the VC group and noticed in 9 (82%) of the non-VC patients at week 48, by intention-to-treat analysis. On treatment analysis, 98% and 100% patients achieved VS in the VC and non-VC groups, respectively. The renal and metabolic tolerance were good. DOR-based regimens appear to be a safe and relevant strategy to circumvent drug interactions and drugs with a poor metabolic tolerance profile.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- weight gain
- peritoneal dialysis
- randomized controlled trial
- healthcare
- prognostic factors
- clinical trial
- body mass index
- hiv infected
- stem cells
- physical activity
- mesenchymal stem cells
- bone marrow
- patient reported
- study protocol
- birth weight