Non-invasive profiling of protease-specific elastin turnover in lung cancer: biomarker potential.
Jeppe Thorlacius-UssingStephanie Nina KehletSarah Rank RønnowMorten Asser KarsdalNicholas WillumsenPublished in: Journal of cancer research and clinical oncology (2018)
Elastin fragments generated by different proteases are elevated in lung cancer patients compared to healthy controls but differ in their presence. This demonstrates non-invasive biomarker potential of elastin fragments in serum from lung cancer patients and suggests that different pathological mechanisms may be responsible for the elastin turnover, warranting further validation in clinical trials.