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Advancing Diagnosis and Treatment in People Living with HIV and Tuberculosis Meningitis.

Sarah KimudaDerrick KasoziSuzan NamombweJane GakuruTimothy MugabiEnock KagimuMorris K RutakingirwaKristoffer E LeonFelicia ChowSean WassermanDavid R BoulwareFiona V CresswellNathan C Bahr
Published in: Current HIV/AIDS reports (2023)
The molecular assay GeneXpert MTB/Rif Ultra has improved sensitivity but has inadequate negative predictive value to "rule-out" TBM. Evaluations of tests focused on the host response and bacterial components are ongoing. Clinical trials are in progress to explore the roles of rifampin, fluoroquinolones, linezolid, and adjunctive aspirin. Though diagnosis has improved, novel modalities are being explored to improve the rapid diagnosis of TBM. Multiple ongoing clinical trials may change current therapies for TBM in the near future.
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