Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.

Tian DuMatthew J SikoraKevin M LevineNilgun TasdemirRebecca B RigginsStacy G WendellBennett Van HoutenSteffi Oesterreich

Published in: Breast cancer research : BCR (2018)

Our characterization of a unique series of AI-resistant ILC models identifies the activation of key regulators of fatty acid and cholesterol metabolism, implicating lipid-metabolic processes driving estrogen-independent growth of ILC cells. Targeting these changes may prove a strategy for prevention and treatment of endocrine resistance for patients with ILC.

Keyphrases

fatty acid
nk cells
induced apoptosis
transcription factor
cell cycle arrest
artificial intelligence
genome wide
cancer therapy
oxidative stress
estrogen receptor
signaling pathway
endoplasmic reticulum stress
machine learning
gene expression