Time-Dependent Potentiation of the PERK Branch of UPR by GPR68 Offers Protection in Brain Ischemia.
Wenyan SunVirendra TiwariGrace DavisGuo-Kun ZhouSarun JonchheXiang-Ming ZhaPublished in: Stroke (2024)
These data demonstrate that GPR68 potentiation leads to neuroprotection, at least in part, through enhancing PERK-eIF2α activation in ischemic tissue but has little impact on healthy tissue.