High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation.
Maaike A SikmaClaudine C HunaultErik M Van MaarseveenAlwin D R HuitemaEd A Van de GraafJohannes H KirkelsMarianne Christina VerhaarJan C GruttersJozef KeseciogluDylan W de LangePublished in: European journal of drug metabolism and pharmacokinetics (2020)
The high variability of tacrolimus pharmacokinetics early after thoracic organ transplantation is largely due to excessive variability in bioavailability, making individualised dosing based on measured concentrations futile. To bypass this bioavailability issue, we suggest administering tacrolimus intravenously and aiming below the upper therapeutic range early post-transplantation. Clinical Trial Registraion: NTR 3912/EudraCT 2012-001909-24.