Recombined humanized endostatin-induced suppression of HMGB1 expression inhibits proliferation of NSCLC cancer cells.

Fan-Jie MengShuo WangYi-Jie YanChun-Yang WangZhi-Yu GuanJun Zhang

Published in: Thoracic cancer (2018)

These results demonstrate the general phenomenon that Rh-endostatin can induce HMGB1 suppression in a variety of NSCLC cells. Rh-endostatin may suppress HMGB1 expression and release in A549 cancer cells, thus inhibiting cell proliferation.

Keyphrases

poor prognosis
small cell lung cancer
cell proliferation
recombinant human
induced apoptosis
advanced non small cell lung cancer
signaling pathway
cell cycle arrest
diabetic rats
long non coding rna
pi k akt
brain metastases
drug induced
endoplasmic reticulum stress
stress induced