Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain-related cognitive dysfunction.

Yan-Ping LiuQiang LiuHaibi WangYongkang QiuJiatao LinWeifeng WuNing WangWei DongJie WanChen ChenShuai LiHui ZhengYu-Qing Wu

Published in: CNS neuroscience & therapeutics (2023)

Reduced SIRT1 expression in hippocampus of SNI mice may induce cognitive impairment associated with chronic pain by mediating the impaired synaptic plasticity.

Keyphrases

chronic pain
cognitive impairment
poor prognosis
oxidative stress
ischemia reperfusion injury
pain management
cerebral ischemia
cell proliferation
signaling pathway
high fat diet induced
long non coding rna
metabolic syndrome
adipose tissue
brain injury
insulin resistance
drug induced