HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer.
Kuang-Tai KuoCheng-Hsin LinChun-Hua WangNarpati Wesa PikatanVijesh Kumar YadavIat-Hang FongChi-Tai YehWei-Hwa LeeWen-Chien HuangPublished in: International journal of molecular sciences (2022)
Therefore, HNMT upregulation in NSCLC cells may upregulate HER2 expression, increasing tumorigenicity and chemoresistance through CSCs maintenance and antioxidant properties. This newly discovered regulatory axis may aid in retarding NSCLC progression and chemoresistance.
Keyphrases
- cancer stem cells
- poor prognosis
- oxidative stress
- induced apoptosis
- small cell lung cancer
- signaling pathway
- advanced non small cell lung cancer
- long non coding rna
- cell proliferation
- cell cycle arrest
- endoplasmic reticulum stress
- dna damage
- brain metastases
- transcription factor
- ischemia reperfusion injury
- diabetic rats
- anti inflammatory
- cell death