MicroRNAs in the Mouse Developing Retina.
Jorge Navarro-CalvoGema EsquivaVioleta Gómez-VicenteLuis M ValorPublished in: International journal of molecular sciences (2023)
The retina is among the highest organized tissues of the central nervous system. To achieve such organization, a finely tuned regulation of developmental processes is required to form the retinal layers that contain the specialized neurons and supporting glial cells to allow precise phototransduction. MicroRNAs are a class of small RNAs with undoubtful roles in fundamental biological processes, including neurodevelopment of the brain and the retina. This review provides a short overview of the most important findings regarding microRNAs in the regulation of retinal development, from the developmental-dependent rearrangement of the microRNA expression program to the key roles of particular microRNAs in the differentiation and maintenance of retinal cell subtypes.
Keyphrases
- diabetic retinopathy
- optic nerve
- optical coherence tomography
- induced apoptosis
- poor prognosis
- gene expression
- cell cycle arrest
- spinal cord
- single cell
- cell therapy
- quality improvement
- oxidative stress
- stem cells
- resting state
- cell death
- endoplasmic reticulum stress
- white matter
- long non coding rna
- spinal cord injury
- cerebrospinal fluid
- blood brain barrier
- binding protein
- brain injury
- functional connectivity