Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
Luca BecariMaria Luiza A FonsecaSthéfanie C A GonçalvesMichael BaderRobson A S SantosMaria José Campagnole-SantosLucas M KangussuPublished in: Acta neuropsychiatrica (2022)
Our data showed that Mas plays an important role in the neurobiology of depression probably by modulating BDNF expression. On the contrary, lack of MrgD did not alter depressive-like behaviour, which was supported by the lack of alterations in BDNF levels.