Myocardial sodium-glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO-AS study.
Lucia ScisciolaPasquale PaolissoMarta BelmonteEmanuele GallinoroLeen DelrueFatemeh TaktazRosaria Anna FontanellaIvan DegrieckAda PesapaneFilip CasselmanArmando PuocciMartina FranzeseFrank Van PraetMichele TorellaRaffaele MarfellaMarisa De FeoJozef BartunekGiuseppe PaolissoEmanuele BarbatoMichelangela BarbieriMarc VanderheydenPublished in: European journal of heart failure (2024)
In patients with LF-LG AS, SGLT2 gene and protein were hyper-expressed in cardiomyocytes and associated with myocardial fibrosis, inflammation, and oxidative stress.
Keyphrases
- left ventricular
- aortic stenosis
- oxidative stress
- aortic valve replacement
- transcatheter aortic valve replacement
- ejection fraction
- transcatheter aortic valve implantation
- aortic valve
- poor prognosis
- binding protein
- heart failure
- dna damage
- early onset
- copy number
- ischemia reperfusion injury
- induced apoptosis
- signaling pathway
- protein protein
- high glucose
- genome wide identification
- endothelial cells
- drug induced
- genome wide analysis