A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors.
Andrea AloiaDaniela MüllhauptChristophe D ChabbertTanja EberhartStefanie Flückiger-MangualAna VukolicOssia M EichhoffAnja IrmischLeila T AlexanderErnesto ScibonaDennie T FrederickBenchun MiaoTian TianChaoran ChengLawrence N KwongZhi WeiRyan J SullivanGenevieve Marie BolandMeenhard HerlynKeith T FlahertyNicola ZamboniReinhard DummerGao ZhangMitchell P LevesqueWilhelm KrekWerner J KovacsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Thus, we identified a clinically relevant therapeutic approach that has the potential to improve initial responses and to delay acquired drug resistance of BRAFV600E -mutant melanoma.