Proinflammatory and Immunomodulatory Gene and Protein Expression Patterns in Spinal Cord and Spleen Following Acute and Chronic High Thoracic Injury.
Felicia M MichaelSamir P PatelAdam D BachstetterAlexander G RabchevskyPublished in: Journal of inflammation research (2023)
Novel temporal-spatial cytokine expression profiles reveal that TNFα protein levels are increased solely in upper thoracic segments after high thoracic SCI, while IFNγ remains unaltered. Splenic leukopenia and latent systemic immunosuppression are not associated with altered TNFα or IFNγ expression in the spleen or spinal cord.
Keyphrases
- spinal cord
- spinal cord injury
- neuropathic pain
- rheumatoid arthritis
- genome wide
- dendritic cells
- immune response
- poor prognosis
- drug induced
- liver failure
- copy number
- respiratory failure
- single cell
- intensive care unit
- dna methylation
- gene expression
- hepatitis b virus
- protein protein
- small molecule
- transcription factor