Clinical Validity of a Prognostic Gene Expression Cluster-Based Model in Human Papillomavirus-Positive Oropharyngeal Carcinoma.
Stefano CavalieriMara S SerafiniAndrea CarenzoSilvana CanevariRuud H BrakenhoffC René LeemansIrene H NautaFrank HoebersMari F C M van den HoutKathrin ScheckenbachThomas K HoffmannLaura ArdighieriTito PoliPasquale QuattroneLaura Deborah LocatiLisa F LicitraLoris De CeccoPublished in: JCO precision oncology (2021)
The rigorous clinical selection of the cases included in this study confirmed the robustness of our three-cluster model in HPV-positive OPCs. The prognostic value was found to be independent and superior compared with TNM8. The next step includes the translation of the three-cluster model in clinical practice. This could open the way to future exploration of already available therapies in HPV-positive OPCs tailoring de-escalation or intensification according to the three-cluster model.