Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.

Liron GanelLei ChenRyan ChristJagadish VangipurapuErica YoungIndraniel DasKrishna KanchiDavid LarsonAllison RegierHaley AbelChul Joo KangAlexandra ScottAki HavulinnaCharleston W K ChiangSusan ServiceNelson FreimerAarno PalotieSamuli RipattiJohanna KuusistoMichael BoehnkeMarkku LaaksoAdam LockeNathan O StitzielIra M Hall

Published in: Human genomics (2021)

These results suggest that measurements of MT-CN in blood-derived DNA partially reflect differences in cell-type composition and that these differences are causally linked to insulin and related traits.

Keyphrases

copy number
genome wide
mitochondrial dna
circulating tumor
endothelial cells
single molecule
type diabetes
cell free
dna methylation
oxidative stress
metabolic syndrome
squamous cell carcinoma
glycemic control
pluripotent stem cells