Granulomas associated with renal neoplasms: A multi-institutional clinicopathological study of 111 cases.
Ankur R SangoiFiona MacleanSambit MohantyOndřej HesReba DanielPriti LalSofia Canete-PortilloCristina Magi-GalluzziKristine M CornejoKatrina CollinsMichael HwangSara M FalzaranoMike M FeelyMelad DababnehLara HarikMaria S TretiakovaMahmut AkgulVarsha ManuchaEmily ChanChia-Sui KaoFarshid SiadatKanika AroraGuliz BarkanLiang ChengMichelle HirschLi LeiMatthew WascoSean R WilliamsonAndres Martin AcostaPublished in: Histopathology (2022)
Based on this largest case-series to date, peri-/intratumoral granulomas associated with renal neoplasms may be more common than initially perceived. The extent of granulomatous inflammation can vary widely and may or may not have necrosis with possible aetiologies, including prior procedure or immunotherapy/chemotherapy. Although a clinical association with sarcoidosis is infrequent it can still occur, and the presence of granulomas warrants mention in pathology reports.