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MDSCs-derived GPR84 induces CD8 + T-cell senescence via p53 activation to suppress the antitumor response.

Jinyan LiuJiayin LiuGuohui QinJiahui LiZiyi FuJieyao LiMiaomiao LiCaijuan GuoMing ZhaoZhen ZhangFeng LiXuan ZhaoLiping WangYi Zhang
Published in: Journal for immunotherapy of cancer (2023)
T cells induces T-cell senescence via the p53 signaling pathway, which could explain the strong immunosuppression of GPR84 endowed to MDSCs.
Keyphrases
  • signaling pathway
  • dna damage
  • endothelial cells
  • fatty acid
  • stress induced
  • pi k akt
  • epithelial mesenchymal transition