Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross-sectional study in Pakistan.
Faiza AlamRehana RehmanSyeda Sadia FatimaMussarat AshrafTaseer Ahmed KhanPublished in: International journal of clinical practice (2021)
The presence of SIRT1 genetic variants (rs10509291 and rs12778366) apparently disturbs the expression of SIRT1 deteriorating mitochondrial antioxidant function within the oocytes, instigating oxidative stress within. Their probable effect on modulating oocyte maturation may be the cause of infertility in females.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- diabetic rats
- dna damage
- induced apoptosis
- poor prognosis
- signaling pathway
- polycystic ovary syndrome
- physical activity
- copy number
- genome wide
- risk factors
- transcription factor
- healthcare
- long non coding rna
- tertiary care
- binding protein
- metabolic syndrome
- dna methylation
- insulin resistance
- gene expression