Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR-γ Signaling.

Jian ZuoMeng-Qing TaoXin-Yue WuTian-Tian JiangOpeyemi Joshua Olatunji Ji-Yang DongJun HanCong-Lan Ji

Published in: Journal of inflammation research (2021)

This study revealed the joint protective advantages of the bioactive fraction from S. inappendiculata in CIA rats over MTX, and demonstrated that S. inappendiculata-derived xanthones suppressed the erosive nature of synovioblast acquired under inflammatory circumstances by regulating PPAR-γ signaling-controlled metabolism-immunity feedback.

Keyphrases

insulin resistance
rheumatoid arthritis
high glucose
oxidative stress
diabetic rats
fatty acid
single cell
adipose tissue
drug induced
type diabetes
metabolic syndrome
skeletal muscle