Login / Signup

Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon.

Robert S ChapkinLaurie A DavidsonHyejin ParkUn-Ho JinYang-Yi FanYating ChengMartha E HenselKerstin K LandrockClinton AllredRani MenonCory KlemashevichArul JayaramanStephen H Safe
Published in: Molecular nutrition & food research (2021)
In colon-derived cells and in the mouse intestine, coffee induced several AhR-dependent responses including gene expression, inhibition of intestinal stem cell-enriched organoid growth, and inhibition of DSS-induced intestinal barrier damage. We conclude that the anti-inflammatory effects of coffee in the intestine are due, in part, to activation of AhR signaling.
Keyphrases