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Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life.

Kyle SalkaMaria ArroyoElizabeth ChorvinskyKarima AbutalebGeovanny F PerezSeth WolfXilei XuchenJered WeinstockMaria J GutierrezMarcos Pérez-LosadaDinesh K PillaiGustavo Nino
Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
IFN-lambda responses to dsRNA in the human infant airway epithelium are regulated by p38-MAPK and NF-kB signalling. High in vivo IFN-lambda production is influenced by virus type and associated with recurrent respiratory sick visits in young children.
Keyphrases
  • immune response
  • early life
  • endothelial cells
  • dendritic cells
  • induced pluripotent stem cells
  • pluripotent stem cells
  • signaling pathway
  • sars cov
  • transcription factor
  • nuclear factor